Asbjoern Andersen


We all know that loud noises can permanently damage our hearing - but that off-the-shelf drugs like aspirin can cause hearing damage is news to me. Here, Karen Collins sheds light on this overlooked risk:
Written by Karen Collins
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Animal Hyperrealism IV Is Here!
 

I’ve never heard anyone speak of what may be even more commonly damaging their ears: medications.

Surprisingly, hearing damage isn’t something we often talk or write about in the world of audio. If anything, we associate hearing damage with loud sounds, and we all know to take precautions against any sounds that may cause damage to our delicate and precious organs. We have SPL meters on our phones and gracefully excuse ourselves from situations that top 90dB, knowing that we may be risking some damage if we stay. We use ear muffs when we’re out recording loud sounds. But I’ve never heard anyone speak of what may be even more commonly damaging their ears: medications.

This includes common drugs like aspirin, acetaminophen (paracetamol), and ibuprofen, but also other painkillers, anti-depressants, antibiotics, and other medications.

Medications that damage hearing are called ototoxic (“oto” meaning “ear” and toxic meaning poisonous!). Our ears are very delicate and sensitive organs, and any medication may have some impact on your hearing. You have most likely taken some ototoxic medications without even knowing it. And for the most part, you probably got away with it. But taking any medication for a long period of time, or in large quantities, can cause permanent, irreversible hearing loss. This includes common drugs like aspirin, acetaminophen (paracetamol), and ibuprofen, but also other painkillers, anti-depressants, antibiotics, and other medications. We rarely read the fine print in taking medications (particularly those we buy off-the-shelf like aspirin), assuming that these are safe if they’re sold in stores everywhere. If we do read the fine print, we assume that the effects are rare. But millions of people are affected by ototoxic medications every single year. Some drugs have an almost 100% guarantee of causing hearing loss! Are you willing to take that risk and potentially do permanent damage to your hearing? I’m not a medical doctor, but I put together this brief guide to raise awareness—talk to your own doctor if you take any medication regularly.
 

How do I know if I’m taking an ototoxic drug?

There are 743 known ototoxic drugs. There is a list of a few here.

Just because a drug is not on that list does not mean it is not ototoxic. Acetaminophen is not on the list, but two studies, in 2010 and 2012, found that acetaminophen is even more toxic than Aspirin and NSAIDs. It is even worse when taken in combination with painkillers (as in the case of Vicodin. I’m always surprised when rock stars get addicted to a drug that will likely cause permanent hearing damage).

There are some studies that suggest that other medications may help to offset the effects (such as melatonin with certain ototoxic anti-cancer drugs)

The first sign of ototoxicity is usually tinnitus (ringing or buzzing in the ears). Other symptoms include light-headedness, vertigo, and hearing loss. If you experience symptoms, talk to your doctor about your medications and if you can, lower the dosage or find an alternative. There are some studies that suggest that other medications may help to offset the effects (such as melatonin with certain ototoxic anti-cancer drugs) . Often the symptoms will go away once the drug has cleared your system. However, sometimes, the damage will be permanent and there is no cure and no treatment to reverse the damage.


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What should I do to protect my hearing?

Be aware of ototoxic medications. If you are on any medication known to be ototoxic, talk to your doctor about finding an alternative. Avoid taking any painkillers if you can tough it out, since pretty much all analgesics and anti-inflammatories are known to be ototoxic. If you are on medication and you get tinnitus, weigh the pros and cons of the medication and talk to your doctor. Let your doctor know that you work in sound and you don’t want to take any ototoxic medications unless absolutely necessary. Do your own research and educate yourself on the risks and benefits of any medication.
 
A drug I take is not on the list of ototoxic medications, but I still have tinnitus.

Talk to your doctor and ask if the drug may be ototoxic. Remember, just because it’s not on the list does not make it safe, and your doctor may not be aware of the risks. Do a Google Scholar search through medical journals and see if others have reported hearing loss or tinnitus with your medication. It could be it’s just not reported, yet, but it may be ototoxic.

Left untreated, and with continued use, ototoxic medications can lead to permanent hearing damage. Be aware. Be careful taking any drug, and let your friends in the audio world know about ototoxicity. Take your health into your own hands and become knowledgeable about your ears.

 

A big thanks to Karen Collins for the insights on this overlooked risk!

 

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    The sound effects are all recorded in 24bit 96khz down to 16bit 44.1khz. These sound effects have been used in many productions such as feature films, video games and all types of broadcast.

    What you get:

    Purchasing this offer gets you a special code that lets you download 50 sound effects from Audiohero.com within a month. The sounds you get with this purchase are covered under the Audiohero EULA.

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    Add this library to the cart and enter ah4launch in the cart coupon field – to sprinkle an extra launch discount, on top of the current discount!

    Animal Hyperrealism Vol IV is a sound library containing animal vocalisations, from real to designed creatures totaling more than 2000 individual sounds in 294 files. The sounds were recorded in zoos, and wildlife centers.

    The asset list includes but is not limited to: hippos, hyenas, vultures, dwarf mongooses, elephants, African cranes, parrots, tigers, pigmy hippos, rhea ostriches, brown bears, pheasants, wildebeests, African wild dogs and many more. The content has been recorded at 192KHz with a Sanken CO100K, an Avisoft CMPA and a Sennheiser 8050 for center plus two Sennheiser MKH8040 for stereo image.

    The resulting ultrasonic spectrum is rich and allows for truly extreme manipulation of the content.

    15 %
    OFF
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    • Both designed hits and source layers for full creative control
    • Covers subtle distant rumbles through to massive cinematic impacts
    • Crafted 100% from synthesis for a unique, larger-than-life sound
    • Perfect for film, games, trailers, and any project needing storm power
    • Created in collaboration with Bruits.Studio’s Vincent Fliniaux and Tibo Csuko (Robotic Lifeforms 2, WATER)

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    The collection comes with hundreds of variations, more than 1 hour of content and many different type of fire spells. It also includes source sounds for more flexibility for your projects.

    This collection is perfect for any films, video games or trailers.

    The library is fully focused on fire spells. You will find simple one shot magic firebolt, powerful high level fire spells, fire sword, berserker enchantments and so on. Spells such as fireball,  firewall, rain of fire, meteor, fire nova, magma storm, pyroblast, sword of Avernus, etc. are included in this library.

     

    THE ARCANE FIRE SPELLS
    38 %
    OFF
  • Immerse yourself in an atmosphere of natural power and tranquility with the “Rain and Thunderstorm” sound collection, consisting of 4 Vol-s.
    This collection features a variety of looped sounds: light rain, night rain with loud thunderclaps, and other effects that will help you create the perfect atmosphere – from a quiet, secluded night, long scenes, or endless atmospheric effects without abrupt transitions, to a dramatic thunderstorm on the horizon.
    The recording was made by a Zoom H3-VR recorder in the Ambisonics A format (96 kHz 24 Bit) and then converted to the AmbiX and Stereo formats (96 kHz 24 Bit), which are located in different folders of this sound pack.


   

One thought on “Ototoxicity: Is your medication damaging your hearing?

  1. Here are the references for the article:

    M. Bisht and S.S. Bist. Ototoxicity: The Hidden Menace. Indian Journal of Otolaryngol head and Neck Surgery, 2011, July Vol 63/3 255-259

    There are separate more in-depth lists of drugs and their effects here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138949/

    S. Curhan, J. Shargorodsky, R. Eavey and G.C. Curhan, Analgesic Use and the Risk of hearing Loss in Women. American Journal of Epidemiology, Volume 176, Issue 6, 15 September 2012, Pages 544–554;

    J. Yorgason, G. Kalinec, W.Luxford, et al. Acetaminophen ototoxicity after acetaminophen/hydrocodone abuse: Evidence from two parallel in vitro mouse models, Otolayrngology—Head and Neck Surgery Vol 142, Issue 6, 2010.

    R.J. Reiter, D.X. Tan, A. Korkmaz, L Fuentes-Broto. Drug-mediated ototoxicity and tinnitus: alleviation with melatonin. Journal of Physiological Pharmacology. April 2011, Vol 62/2 151-7.

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